Please use this identifier to cite or link to this item: http://hdl.handle.net/11717/16418
Title: Energetic and topological determinants of a phosphorylation-induced disorder-to-order protein conformational switch
Authors: Gopi, S.
Rajasekaran, N.
Singh, A.
Ranu, S.
Naganathan, A.N.
Issue Date: 2015
Publisher: Royal Society of Chemistry
Citation: Physical Chemistry Chemical Physics, 17(41), 27264-27269
Abstract: We show that the phosphorylation of 4E-BP2 acts as a triggering event to shape its folding-function landscape that is delicately balanced between conflicting favorable energetics and intrinsically unfavorable topological connectivity. We further provide first evidence that the fitness landscapes of proteins at the threshold of disorder can differ considerably from ordered domains. This journal is � the Owner Societies 2015.
URI: http://dx.doi.org/10.1039/c5cp04765j
http://hdl.handle.net/11717/16418
ISSN: 14639076
Appears in Collections:Articles

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