Please use this identifier to cite or link to this item:
Title: Energetic and topological determinants of a phosphorylation-induced disorder-to-order protein conformational switch
Authors: Gopi, S.
Rajasekaran, N.
Singh, A.
Ranu, S.
Naganathan, A.N.
Issue Date: 2015
Publisher: Royal Society of Chemistry
Citation: Physical Chemistry Chemical Physics, 17(41), 27264-27269
Abstract: We show that the phosphorylation of 4E-BP2 acts as a triggering event to shape its folding-function landscape that is delicately balanced between conflicting favorable energetics and intrinsically unfavorable topological connectivity. We further provide first evidence that the fitness landscapes of proteins at the threshold of disorder can differ considerably from ordered domains. This journal is � the Owner Societies 2015.
ISSN: 14639076
Appears in Collections:Articles

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.