Please use this identifier to cite or link to this item: http://hdl.handle.net/11717/3975
Title: Biradicals as ESR probes of conformations in model ?-turn peptides
Authors: Sankarapandi, S.
Sukumar, M.
Balaram, P.
Manoharan, P.T.
Keywords: peptide; radical; solvent; thiol group; amino acid sequence; electron spin resonance; priority journal; protein conformation; spin labeling; temperature; Amino Acid Sequence; Electron Spin Resonance Spectroscopy; Free Radicals; Molecular Sequence Data; Peptides; Protein Conformation; Protein Folding; Protein Structure, Secondary; Solvents; Spin Labels; Sulfhydryl Compounds; Support, Non-U.S. Gov't; Temperature
Issue Date: 1995
Citation: Biochemical and Biophysical Research Communications, 213(2), 439-446
Abstract: Electron spin-spin exchange interaction in biradicals has been examined for its potential usefulness in the conformational analysis of peptides in solution. Three peptides with high propensity to adopt ?-turn conformations in solution, Boc-Cys-Pro-Xxx-Cys-NHMe (Xxx = Leu, 1; Xxx = Aib, 2; Xxx = Tyr, 3), have been modified into biradicals by spin labeling the thiols groups. Analysis of electron spin resonance spectra of these peptides in it variety of solvents and at different temperatures suggests that the population of folded conformations follows the order 2 > 1 > 3.
URI: http://dx.doi.org/10.1006/bbrc.1995.2151
http://hdl.handle.net/11717/3975
ISSN: 0006291X
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