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Biocatalytic reduction of Î±-keto amides to (R)-Î±-hydroxy amides using Candida parapsilosis ATCC 7330
(30-12-2012)
Stella, Selvaraj
;
Anju Chadha
Biocatalytic reduction of primary and secondary α-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-α-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88-99%) as compared to the secondary (R)-α-hydroxy amides. © 2012 Elsevier B.V.