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Dhiman Chatterjee
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Dhiman Chatterjee
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Dhiman Chatterjee
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Chatterjee, Dhiman
Chatterjee, D.
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5 results
Now showing 1 - 5 of 5
- PublicationDesign and development of a piezoelectrically actuated micropump for drug delivery application(01-01-2014)
;Eladi, Paul Braineard; Micropumps form the heart of several microfluidic systems like micro total analysis system (µTAS) and drug delivery devices, which have resulted from the advancement of silicon micromachining technology. Among the different available types of micropumps, valveless micropumps are better suited for biological applications as they do not have flow-rectifying valves and are less prone to clogging and wear. However, their main drawback is low thermodynamic efficiency. This can be improved if we have a better understanding of the effects of geometry on the performance. This forms one of the objectives of this work. This chapter describes the activity on the design and development of valveless micropumps. A numerical parametric study of the performance of valveless micropumps has been carried out and is presented to bring out the effects of different geometrical parameters. Based on these design approaches, silicon-based micropumps are fabricated and characterized. The performance of one of these micropumps is compared with designed value in this work. - PublicationA Novel Integrated Transdermal Drug Delivery System with Micropump and Microneedle Made from Polymers(01-01-2023)
;Attiguppe, Ajay Prabhakar; Transdermal drug delivery (TDD), which enables targeted delivery with microdosing possibilities, has seen much progress in the past few years. This allows medical professionals to create bespoke treatment regimens and improve drug adherence through real-time monitoring. TDD also increases the effectiveness of the drugs in much smaller quantities. The use of polymers in the drug delivery field is on the rise owing to their low cost, scalability and ease of manufacture along with drug and bio-compatibility. In this work, we present the design, development and characterization of a polymer-based TDD platform fabricated using additive manufacturing technologies. The system consists of a polymer based micropump integrated with a drug reservoir fabricated by 3D printing and a polymer hollow microneedle array fabricated using photolithography. To the best of our knowledge, we present the fabrication and characterization of a 3D-printed piezoelectrically actuated non-planar valveless micropump and reservoir integrated with a polymer hollow microneedle array for the first time. The integrated system is capable of delivering water at a maximum flow rate of 1.03 mL/min and shows a maximum backpressure of 1.37 kPa while consuming only 400 mW. The system has the least number of moving parts. It can be easily fabricated using additive manufacturing technologies, and it is found to be suitable for drug delivery applications. - PublicationFabrication of monolithic SU-8 microneedle arrays having different needle geometries using a simplified process(01-06-2021)
;Ajay, A. P.; Transdermal drug delivery using hollow microneedle enables creating small, wearable and minimally invasive closed-loop system. Polymer hollow microneedles are preferable because they are cost-effective and easy to manufacture. SU-8 is chosen for creating the hollow microneedles as it is a biocompatible photopolymer with robust mechanical properties. Previously reported SU-8 microneedles either use melt casting process for coating SU-8 which is laborious or do not have monolithic structures, thereby making these mechanically weak and difficult to integrate. To the best of our knowledge, for the first time, we report the use of a single-step spin coating process to achieve the desired thickness of SU-8 while using UV lithography to create a monolithic microneedle array. Three types of microneedles were fabricated with outer dimensions varying from 90 to 180 μm, and lumen dimensions ranging from 60 to 80 μm and needle height of 600 μm. These needles are fabricated in a 10×10 array with a platform thickness of 300 μm. Geometrical, mechanical and fluid flow characterisations are carried out for the fabricated arrays. We report the use of a non-destructive evaluation method to characterise the lumen of the fabricated microneedles. The fabricated needles are robust and offer low resistance to fluid flow. The triangular needles can withstand a bending load of 0.2 N and an axial load of 0.7 N. The needles with circular lumen offer least resistance to fluid flow of 0.2 Pa-min μL−1. - PublicationAn efficient numerical method for predicting the performance of valveless micropump(01-11-2012)
;Eladi, Paul Braineard; Numerical characterization of valveless micropumps involves fluid-structure interaction (FSI) between a membrane and the working fluid. FSI being computationally difficult, efforts have been mainly restricted to analyzing a given micropump performance. Designing an optimum micropump involves understanding the role of different geometric parameters and this forms the focus of the present work. It is shown that membrane displacement information extracted from a two-way coupled FSI simulation at a given frequency can be reliably used to carry out fluid flow simulations over a wide range of geometrical and operating parameters. The maximum variation between this approach and FSI is within 4% while there is a drastic reduction in computational time and resource. A micropump structure suitable for MEMS technology is considered in this work. An optimum micropump geometry, having a pump chamber height of 50μm, diffuser length of 280μm, throat width of 100μm and separation distance between nozzle and diffuser openings of 2.5mm, is recommended. The numerical prediction of flowrate at 200Hz (68μlmin 1) for this pyramidal valveless micropump matches well with the experimental data (60μlmin 1) of the micropump fabricated using MEMS-based silicon micromachining. Thus an efficient numerical method to design valveless micropumps is proposed and validated through rigorous characterization. © 2012 IOP Publishing Ltd. - PublicationExperimental characterization of piezoelectrically actuated micromachined silicon valveless micropump(01-01-2017)
;Aggarwal, Shelly ;Paul, Braineard Eladi; In this paper, performance of piezoelectrically actuated pyramidal valveless micropumps is studied experimentally in detail. Valveless micropumps based on silicon and glass substrate are fabricated using MEMS technology. Two different sizes of micropumps having overall dimensions of 5 mm × 5 mm × 1 mm and 10 mm × 10 mm × 1 mm are fabricated and characterized. In the fabricated micropumps, the thickness of silicon diaphragm is <20 µm which gives the advantage of operating pump at low voltage with excellent stability and consistency. The performance of micropumps in terms of flowrate and backpressure is evaluated for a wide range of driving frequency and actuating voltages. The maximum flowrate of water in the 10-mm micropump is 355 µl/min and backpressure of 3.1 kPa at zero flowrate for an applied voltage of 80 V at frequency 1.05 kHz. The reported micropumps have low footprint, high flowrate and backpressure. Thus, these micropumps are especially suited for biological applications as these can withstand adequate amount of backpressure. Comparative study of the performance of these micropumps with those available in the literature brings out the efficacy of these micropumps.