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Venkitasamy Kesavan
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Venkitasamy Kesavan
Official Name
Venkitasamy Kesavan
Alternative Name
Kesavan, Venkitasamay
Venkitasamy, Kesavan
Kesavan, Venkitasamy
Kesavan, Ventikasamy
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6 results
Now showing 1 - 6 of 6
- PublicationConstruction of Polycyclic Fused Pyrrolidines with Three Contiguous Stereocenters via Michael Addition of Vinylmalononitriles to Nitrostyrenes Using l -Proline-Derived Thiourea(16-08-2016)
;Vishwanath, Manjunatha ;Prakash, Muthuraj ;Vinayagam, PoopathyThe catalytic efficiency of a bifunctional chiral thiourea derived from l-proline was evaluated in the asymmetric direct vinylogous Michael reaction of α,α-dicyanoolefins to β-nitrostyrenes with an electron-releasing or electron-withdrawing substituent in various positions. The corresponding adducts were isolated in good yields, with excellent diastereo- (>99%) and enantioselectivity (up to 95%). The Michael adducts were further functionalized to achieve the synthesis of polycyclic fused pyrrolidines with three contiguous stereocenters in good enantioselectivities. - PublicationNew class of bifunctional thioureas from l-proline: Highly enantioselective Michael addition of 1,3-dicarbonyls to nitroolefins(15-04-2014)
;Vinayagam, Poopathy ;Vishwanath, ManjunathaA new class of bifunctional tertiary amine thiourea was synthesized from l-proline. The reported thiourea is amenable to steric and electronic modifications at the stereogenic center bearing a thiourea moiety. Excellent enantioselectivity was obtained in the Michael addition of 2,4-pentanedione to various nitro olefins using the new organocatalyst. The construction of contiguous stereocenters via the Michael reaction of substituted 1,3-dicarbonyls to nitro olefins was also carried out with very good yield, enantioselectivity, and diastereoselectivity. © 2014 Elsevier Ltd. All rights reserved. - PublicationAsymmetric Organocatalytic Assembly of Oxindoles Fused with Spiro-3,4-dihydropyrans with Three Contiguous Stereocenters Consisting of Vicinal Quaternary Centers(01-05-2016)
;Vishwanath, Manjunatha ;Vinayagam, Poopathy ;Gajulapalli, V. Pratap ReddyDiverse bispiro-3,4-dihydropyrans consisting of oxindole moieties with three contiguous chiral centers and vicinal quaternary stereocenters were synthesized with very good yields of up to 92% and excellent enantioselectivity of up to 99% ee by using a proline-derived thiourea organocatalyst. - PublicationOrganocatalytic asymmetric decarboxylative cyanomethylation of isatins using l-proline derived bifunctional thiourea(28-06-2014)
;Pratap Reddy Gajulapalli, V. ;Vinayagam, PoopathyFirst asymmetric decarboxylative cyanomethylation of isatins is reported herewith using bifunctional thiourea derived from l-proline in good yields and enantioselectivities. This strategy enables the construction of various 3-cyanomethylene substituted 3-hydroxyoxindoles in enantioselective manner. Enantioselective synthesis of CPC-1 alkaloid has been accomplished in fewer steps. This journal is © the Partner Organisations 2014. - PublicationErratum: New class of bifunctional thioureas from l-proline: Highly enantioselective Michael addition of 1,3-dicarbonyls to nitroolefins (Tetrahedron Asymmetry (2014) 25 (568-577))(15-09-2014)
;Vinayagam, Poopathy ;Vishwanath, Manjunatha - PublicationEnantioselective assembly of functionalized carbocyclic spirooxindoles using an L-proline derived thiourea organocatalyst(01-01-2015)
;Reddy Gajulapalli, V. Pratap ;Vinayagam, PoopathySequential vinylogous Michael addition-cyclization reactions of vinyl malononitriles with isatylidene malononitrile were accomplished using l-proline derived bifunctional thiourea. Cyclohexylidine malononitrile afforded exclusively the single diastereomer with good to excellent enantioselectivity (up to 99% ee) for diverse oxindole spirocyclohexene derivatives. Tetralone derived α,α-dicyano alkene was also employed to access spirocyclic oxindole scaffolds with an excellent level of stereoselectivity (up to 99% ee).