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S Sundar
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S Sundar
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S Sundar
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Sundar, Subbiah
Sundar, S.
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2 results
Now showing 1 - 2 of 2
- PublicationMathematical investigation of drug dispersion in the blood flow through Stenotic-Aneurysm tapered blood vessel(01-01-2023)
;Reddy, J. V.Ramana ;Ha, HojinThis study investigates the hemodynamics of nanofluid flow through modelled stenosis-aneurysm models. The models were created using mathematical functions to increase their realism. This study aims to explore how temperature-sensitive drugs coated on nanoparticles could be delivered to diseased areas, with the mathematical model aiding in the treatment of vascular stenosis. To effectively treat stenosis, medication-coated nanoparticles should be applied to the exterior surface of a catheter. The blood flow was modelled as a micropolar fluid flow, which led to the development of highly nonlinear coupled equations for momentum, temperature, and concentration. The dispersion of nanoparticles resulted in changing viscosity effects, making the fluid flow equations even more complex. The model considered the porous nature of the stenosis, no-slip at the catheter surface, and free slip at the blood vessel surface. The homotopy perturbation method was used to solve the formulated mathematical model. The study investigated the convergence of perturbed solutions for temperature and concentration and showed the degree of deformation. Drug delivery to a targeted region is faster in a converging tapered blood vessel than in a diverging and non-tapered artery. Concentration dispersion is more significant in the stenotic region, while temperature dispersion is more significant in the aneurysm region. The results of the study can be used to understand the improvement in mass dispersion and heat transfer in unhealthy blood arteries, which may be useful in delivering drugs to treat stenotic diseases. - PublicationModelling and simulation of fluid flow through stenosis and aneurysm blood vessel: a computational hemodynamic analysis(01-01-2023)
;Ramana Reddy, J. V. ;Ha, HojinIn this article, the hemodynamics of nanofluid flow through the modelled stenosis-aneurysm models in the presence of the catheter has been studied. The eight stenosis-aneurysm models are developed to mimic biological observations and thus make the model more realistic. The mathematical understanding helps in treating the stenosis in the blood vessel by targeting the unhealthy region to the drug, which is coated on nanoparticles. The catheter achieves the active drug release to the aimed organs by coating on the catheter surface, which adds additional benefits. In the present hemodynamic study, the blood is modeled as a couple stress fluid; as a result, the highly non-linear momentum, temperature, and concentration equations were obtained. The fluid flow equations’ complexity is further increased by incorporating the variable viscosity effects that arose due to the suspension of nanoparticles. The resultant mathematical model is solved by using the homotopy perturbation method. The convergence of the perturbed solutions is studied and depicted the degree of deformation in the case of temperature and concentration. The effects of the porous nature of the stenosis, no-slip at the catheter surface, and the free slip at the blood vessel boundary in the non-stenotic region are also considered in the model. The essential physiological property like surface shear stress is computed, and various parameters’ influence on shear stress is analyzed. The present analysis can be helpful in understanding the enhancement in mass dispersion and heat transfer in unhealthy blood vessels, which could be used for drug delivery in the treatment of stenotic conditions.