Publication:
A Novel Integrated Transdermal Drug Delivery System with Micropump and Microneedle Made from Polymers

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cris.virtual.author-orcid0000-0002-1644-2781
cris.virtual.author-orcid0000-0001-6994-8447
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.departmentIndian Institute of Technology, Madras
cris.virtual.departmentIndian Institute of Technology, Madras
cris.virtual.department#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcide02eb274-54c2-4fef-8c21-64af0f94c4b2
cris.virtualsource.author-orcidb474b936-fd7b-4c6d-bcae-aae8f3309625
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.departmente02eb274-54c2-4fef-8c21-64af0f94c4b2
cris.virtualsource.departmentb474b936-fd7b-4c6d-bcae-aae8f3309625
cris.virtualsource.department#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.contributor.authorAttiguppe, Ajay Prabhakar
dc.contributor.authorDhiman Chatterjee
dc.contributor.authorAmitava Das Gupta
dc.date.accessioned2023-09-19T13:28:12Z
dc.date.available2023-09-19T13:28:12Z
dc.date.issued01-01-2023
dc.description.abstractTransdermal drug delivery (TDD), which enables targeted delivery with microdosing possibilities, has seen much progress in the past few years. This allows medical professionals to create bespoke treatment regimens and improve drug adherence through real-time monitoring. TDD also increases the effectiveness of the drugs in much smaller quantities. The use of polymers in the drug delivery field is on the rise owing to their low cost, scalability and ease of manufacture along with drug and bio-compatibility. In this work, we present the design, development and characterization of a polymer-based TDD platform fabricated using additive manufacturing technologies. The system consists of a polymer based micropump integrated with a drug reservoir fabricated by 3D printing and a polymer hollow microneedle array fabricated using photolithography. To the best of our knowledge, we present the fabrication and characterization of a 3D-printed piezoelectrically actuated non-planar valveless micropump and reservoir integrated with a polymer hollow microneedle array for the first time. The integrated system is capable of delivering water at a maximum flow rate of 1.03 mL/min and shows a maximum backpressure of 1.37 kPa while consuming only 400 mW. The system has the least number of moving parts. It can be easily fabricated using additive manufacturing technologies, and it is found to be suitable for drug delivery applications.
dc.identifier.doi10.3390/mi14010071
dc.identifier.scopus2-s2.0-85146433022
dc.identifier.urihttps://apicris.irins.org/handle/IITM2023/18520
dc.relation.ispartofseriesMicromachines
dc.sourceMicromachines
dc.subjectintegrated drug delivery
dc.subjectmicrodosing system
dc.subjectnon-planar valveless micropump
dc.subjectpolymer hollow microneedle
dc.subjectpolymer integrated drug delivery
dc.subjectpolymer valveless micropump
dc.subjecttransdermal drug delivery
dc.titleA Novel Integrated Transdermal Drug Delivery System with Micropump and Microneedle Made from Polymers
dc.typeJournal
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume14
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationIndian Institute of Technology, Madras
oairecerif.author.affiliationIndian Institute of Technology, Madras
person.affiliation.cityChennai
person.affiliation.id60025757
person.affiliation.nameIndian Institute of Technology Madras
person.identifier.scopus-author-id58069032000
person.identifier.scopus-author-id7102524728
person.identifier.scopus-author-id35786972800
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