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Tandem alkylation - Michael addition to vinylogous carbonates for the stereoselective construction of 2,3,3,6-tetrasubstituted tetrahydropyrans
Date Issued
18-06-2009
Author(s)
Gharpure, Santosh J.
Reddy, S. Raja Bhushan
Abstract
A stereoselective method for the synthesis of substituted tetrahydropyran derivatives employing a tandem SN2-Michael addition sequence to vinylogous carbonates is developed. The method is extended to the synthesis of bicyclic ether motifs present in polyether ladder toxins. © 2009 American Chemical Society.
Volume
11