Convenient enantiopure synthesis of (2S,3R)-2-O-benzyl-3,4-O- isopropylidene-D-erythritol from D-(+)-glucono-δ-lactone: A potential C<inf>4</inf> chiral building block

A new convenient synthesis of (2S,3R)-2-O-benzyl-3,4-O-isopropylidene-D- erythritol has been achieved starting from extremely cheap and commercially available D-(+)-glucono-δ-lactone. It involves two carbon excisions using ozonolysis. The inbuilt stereochemistry ensures the enantiopurity of the target compound. © Georg Thieme Verlag Stuttgart.