Equilibrium Study On Binary Complexes Of Cu(II), Ni(II) Co(II) And Mg(II) With Nucleic Acid Bases

Formation constants of 1:1 binary complexes of Cu(II). Ni(II), Co(III) and Mg(II) with nucleic acid bases such as adenine, 8-azaadenine, cytosine and uracil are reported at 30° at an ionic strength of 0.1M (KNO3). The acid dissociation constants of the above ligands are reported at 30 and 60° together with the thermodynamic parameters involved in their dissociation reactions. In general the first dissociation is favourable and the stability of the 1:1 metal complexes decreases in the order Cu(II) > NK(II) > Co(II) > Mg(II). There is a good correlation between the basicity of the ligands and the stability of the 1:1 metal complexes. No significant interaction is observed in the case of uracil with any of the metal ions investigated. © 1983, Taylor & Francis Group, LLC. All rights reserved.