Stereoselective synthesis of oxazino[4,3-a]indoles employing the oxa-Pictet–Spengler reaction of indoles bearing N-tethered vinylogous carbonate

A one-pot, sequential 2,3-bis-functionalization of indoles bearing N-tethered vinylogous carbonates employing an intramolecular oxa-Pictet–Spengler reaction followed by electrophilic substitution is developed for the stereoselective synthesis of oxazino[4,3-a]indoles. © 2011 The Royal Society of Chemistry.