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Microfluidic devices in advanced caenorhabditis elegans research

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cris.author.scopus-author-id55141833900
cris.author.scopus-author-id36061477800
cris.virtual.departmentIndian Institute of Technology, Madras
cris.virtual.department#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.department99df1b00-2d34-4296-aeab-1dd0586f9624
cris.virtualsource.department#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.contributor.authorShanmugam, Muniesh Muthaiyan
dc.contributor.authorTuhin Subhra Santra
dc.date.accessioned2023-09-20T05:12:50Z
dc.date.available2023-09-20T05:12:50Z
dc.date.issued01-08-2016
dc.description.abstractThe study of model organisms is very important in view of their potential for application to human therapeutic uses. One such model organism is the nematode worm, Caenorhabditis elegans. As a nematode, C. Elegans have ∼65% similarity with human disease genes and, therefore, studies on C. Elegans can be translated to human, as well as, C. Elegans can be used in the study of different types of parasitic worms that infect other living organisms. In the past decade, many efforts have been undertaken to establish interdisciplinary research collaborations between biologists, physicists and engineers in order to develop microfluidic devices to study the biology of C. Elegans. Microfluidic devices with the power to manipulate and detect bio-samples, regents or biomolecules in micro-scale environments can well fulfill the requirement to handle worms under proper laboratory conditions, thereby significantly increasing research productivity and knowledge. The recent development of different kinds of microfluidic devices with ultra-high throughput platforms has enabled researchers to carry out worm population studies. Microfluidic devices primarily comprises of chambers, channels and valves, wherein worms can be cultured, immobilized, imaged, etc. Microfluidic devices have been adapted to study various worm behaviors, including that deepen our understanding of neuromuscular connectivity and functions. This review will provide a clear account of the vital involvement of microfluidic devices in worm biology.
dc.identifier.doi10.3390/molecules21081006
dc.identifier.pmid27490525
dc.identifier.scopus2-s2.0-84982740690
dc.identifier.urihttps://apicris.irins.org/handle/IITM2023/38278
dc.relation.ispartofseriesMolecules
dc.sourceMolecules
dc.subjectC. Elegans
dc.subjectMicrofluidics devices
dc.subjectModel organism
dc.subjectNematode worm
dc.subjectWorm chips
dc.subjectWorm immobilization
dc.titleMicrofluidic devices in advanced caenorhabditis elegans research
dc.typeJournal
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.volume21
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationIndian Institute of Technology, Madras
person.affiliation.cityChennai
person.affiliation.cityHsinchu
person.affiliation.id60025757
person.affiliation.id60018029
person.affiliation.nameIndian Institute of Technology Madras
person.affiliation.nameNational Tsing Hua University
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