The effect of micro- and macromixing on enzyme reaction in a real CSTR

The effect of micromixing and macromixing on enzyme reaction of Michaelis-Menten type in a real continuously stirred tank reactor (CSTR) is considered. The effect of bypassing of a fraction of feed stream, dead space, initial enzyme concentration and Michaelis-Menten constant on substrate conversion is evaluated. Bypass reduces the substrate conversion significantly compared with other parameters in the case of micro and macromixing. Micromixing predicts higher substrate conversions compared with macromixing. The effect of micro and macromixing on substrate conversion is negligible at low and high conversions. © 1993 Springer-Verlag.