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Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: Pyrimidine as an easily removable C-H directing group
Date Issued
01-01-2015
Author(s)
Kumar, Govindharaj
Indian Institute of Technology, Madras
Abstract
Pyrimidine is successfully used as an easily removable C(sp<sup>2</sup>)-H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C-H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1H-indoles and aldehydes. Easy removal of the pyrimidine directing group using EtONa in DMSO provides C2-acyl indoles.
Volume
5