Synthesis of 1,2,3-Triazole Tethered 3-Hydroxy-2-oxindoles: Promising Corrosion Inhibitors for Steel in Acidic Medium and Their Anti-Microbial Evaluation

Herein, we designed and synthesizeda series of 1,2,3-triazole tethered 3-hydroxy-2-oxindoles (4 a-j) using N-propargyl isatin derivatives as key starting materials (1 a-d) under ball-milling conditions by merging aldol condensation and click reaction. The synthesized compounds (4 a-j) were examined for their corrosion inhibition behavior in mild steel using gravimetric and electrochemical analysis. The compound 4 i was identified as the most efficient compound with an efficiency of >70%. Also, the adsorption of inhibitors on the surface of mild steel and mixed type of behaviors was evidenced by impedance and Tafel polarization studies, respectively. Further, the evaluation of antibacterial and antifungal activities demonstrated that compound 4 gpossessed a significant potential to behave as an antimicrobial agent.