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Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B
Date Issued
01-01-1989
Author(s)
Subhashini, M.
Subramanian, M. S.
Rao, V. R.S.
Abstract
A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 μg of INH can be determined. © 1990.
Volume
7