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o-Quinone methide based approach to isoflavans: application to the total syntheses of equol, 3′-hydroxyequol and vestitol

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28-04-2008
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Research Projects
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Abstract
A concise strategy is developed for the synthesis of isoflavans employing a Diels-Alder reaction between o-quinone methides and aryl-substituted enol ethers followed by reductive cleavage of the acetal group. The method is extended towards the total syntheses of equol, 3′-hydroxyequol and vestitol. © 2008 Elsevier Ltd. All rights reserved.
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Diels-Alder reaction, Equol, Hydroxyequol, Isoflavonoids, o-Quinone methides, Vestitol
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