Natural and synthetic glycosylated chalcones as promising bioactive compounds

The glycosylated chalcones are being revisited as promising chemical scaffolds in medicinal chemistry because of their improved bioavailability compared to aglycone chalcones. This article briefly highlights the natural O- and C-glycosylated chalcones present in literature and presents the summary of our recent synthesis of C-glucosylated isoliquiritigenin, a C-glucosylated chalcone with promising aldose reductase inhibition properties.