Domino Oxidative Esterification of 2-Oxo Alcohol Using 2-Iodoxybenzoic Acid/I<inf>2</inf>: A Route to Synthesize α-Ketoester

Date Issued
31-07-2018
Author(s)
Sundaravelu, Nallappan
Chakraborty, Ankush
Indian Institute of Technology, Madras
DOI
Abstract
An efficient metal-free methodology for the synthesis of α-ketoesters has been developed using α-hydroxy ketones and alcohols which follows domino alcohol oxidation and esterification reaction sequence. This methodology shows wide range of substrate scopes to bestow the products in excellent yield. A gram scale synthesis has been carried out to show the practical utility of the protocol.
Volume
3
Subjects