Cationic Amphiphilic Molecules as Bactericidal Agents

Cationic amphiphiles belong to the large as well as assorted category of antimicrobial agents, which has emerged as a sizzling topic of discussion among scientists these days. These antibacterial molecules are being evaluated preclinically and clinically for the treatment of infection caused by drug-resistant bacteria. Due to the widespread application of the cationic amphiphilic molecule (CAM), it’s vital to know the effects and detailed chemistry related to the solid surfaces, degrees of confinement on aggregation morphologies, plus chemical kinetics in the self-assemblies of cationic amphiphilic systems. This chapter has included the points described above and phase transitions exhibited by CAMs in the peptides. CAM offers a new tool designed for scientific research with various industrialized applications required for bacterial membrane permeabilizations by optimizing the goal of antibacterial activity, reaching the target drugs, and thereby compromising their structural integrity by cell rupture and death. These results revealed that the varied supramolecular morphologies of CAMs could be controlled by tuning ionic-hydrophobic, hydrophobic-hydrophobic, ionic-hydrophilic, and charge-transfer interactions.