Association of Local Arterial Stiffness and Windkessel Model Parameters with Ageing in Normotensives and Hypertensives

Computation of arterial stiffness is a well-established, widely accepted method for estimating vascular age. Although carotid-femoral pulse wave velocity is typically used for vascular age assessment, most recent studies have reported the need to consider a combination of local and regional stiffness indices possessing distinct association with the vascular structure and/or function for better prediction of early vascular ageing syndrome. In this work, we investigate the association of clinically validated local stiffness (obtained using biomechanical relations), global stiffness (obtained from 3-element Windkessel modelling), and pulse contour indices from the aorta with ageing and their distribution in normotensives and hypertensives. The analysis was performed on 420 (virtual) subjects (age: 65 ± 11 years) with an equal proportion of hypertensive (age: 65 ± 11 years) and normotensive (age: 65 ± 11 years) subjects. Multivariate linear regression analysis revealed an independent association of each of the indices with age (Adjusted r = 0.75 p < 0.01). Specific stiffness index (r = 0.67, p < 0.001), Augmentation index (r = 0.55, p< 0.001) and total arterial compliance (r = -0.50, p < 0.001) depicted highest correlation with age. There was a significant difference (> 16%, p < 0.001) in mean values of the measured indices between hypertensive and normotensive subjects. The study findings further emphasize the need to combine multiple non-invasive vascular markers to capture the unique aspects of age-induced arterial wall remodelling for reliable monitoring and management of the early vascular ageing syndrome. Clinical Relevance- This study demonstrates an independent and combined predictive role of local/global stiffness and pulse contour indices in ageing.