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  1. Home
  2. Indian Institute of Technology Madras
  3. Publication6
  4. A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium
 
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A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium

Date Issued
01-01-2017
Author(s)
Basak, Debajyoti
Sridhar, Sucheta
Amal Kanti Bera 
Indian Institute of Technology, Madras
Madhavan, Nandita
DOI
10.1016/j.bmcl.2017.04.081
Abstract
Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport.
Volume
27
Subjects
  • Amphiphiles

  • Ion channels

  • Peptides

  • Pores

  • Sodium transport

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