Repository logo
  • English
  • Català
  • Čeština
  • Deutsch
  • Español
  • Français
  • Gàidhlig
  • Italiano
  • Latviešu
  • Magyar
  • Nederlands
  • Polski
  • Português
  • Português do Brasil
  • Suomi
  • Svenska
  • Türkçe
  • Қазақ
  • বাংলা
  • हिंदी
  • Ελληνικά
  • Yкраї́нська
  • Log In
    or
    New user? Click here to register.Have you forgotten your password?
Repository logo
  • Communities & Collections
  • Research Outputs
  • Fundings & Projects
  • People
  • Statistics
  • English
  • Català
  • Čeština
  • Deutsch
  • Español
  • Français
  • Gàidhlig
  • Italiano
  • Latviešu
  • Magyar
  • Nederlands
  • Polski
  • Português
  • Português do Brasil
  • Suomi
  • Svenska
  • Türkçe
  • Қазақ
  • বাংলা
  • हिंदी
  • Ελληνικά
  • Yкраї́нська
  • Log In
    or
    New user? Click here to register.Have you forgotten your password?
  1. Home
  2. Indian Institute of Technology Madras
  3. Publication1
  4. Discovering design principles for biological functionalities: Perspectives from systems biology
 
  • Details
Options

Discovering design principles for biological functionalities: Perspectives from systems biology

Date Issued
01-12-2022
Author(s)
Bhattacharya, Priyan
Karthik Raman 
Indian Institute of Technology, Madras
Arun K Tangirala 
Indian Institute of Technology, Madras
DOI
10.1007/s12038-022-00293-4
Abstract
Network architecture plays a crucial role in governing the dynamics of any biological network. Further, network structures have been shown to remain conserved across organisms for a given phenotype. Therefore, the mapping between network structures and the output functionality not only aids in understanding of biological systems but also finds application in synthetic biology and therapeutics. Based on the approaches involved, most of the efforts hitherto invested in this field can be classified into three broad categories, namely, computational efforts, rule-based methods and systems-theoretic approaches. The present review provides a qualitative and quantitative study of all three approaches in the light of three well-researched biological phenotypes, namely, oscillation, toggle switching, and adaptation. We also discuss the advantages, limitations, and future research scope for all three approaches along with their possible applications to other emergent properties of biological relevance.
Volume
47
Subjects
  • Adaptation

  • biological networks

  • bioswitches

  • computational approac...

  • oscillator

  • rule-based

  • systems biology

  • systems theory

Indian Institute of Technology Madras Knowledge Repository developed and maintained by the Library

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Cookie settings
  • Privacy policy
  • End User Agreement
  • Send Feedback