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Correction to: Structure–function relationship and physiological role of apelin and its G protein coupled receptor (Biophysical Reviews, (2023), 15, 1, (127-143), 10.1007/s12551-023-01044-x)
Date Issued
01-04-2023
Author(s)
Murali, Subhashree
Indian Institute of Technology, Madras
Abstract
In this article, Figure 1 was published with incorrect image. The corrected Figure 1 is shown here. (Figure presented.) a Representation of crystal structure of APJR-AMG3054 complex (PDB: 5VBL). The modified peptide ligand is depicted in green (sticks) and the receptor is shown in orange (cartoon). b Amino acid sequence of apelin peptide isoforms. Residues of Apelin-36, Apelin-17, Apelin-13, and Pyro-glutamate (Pyr) Apelin-13 are indicated. Grey arrows show the site of cleavage by PCSK3/furin enzyme in the larger isoforms, Apelin-36 and Apelin-17 c Comparison between Apelin-17 and AMG3054. The latter is a modified cyclic peptide (cyclised between Glu10 and Lys13, indicated by dotted lines). The modified residues of AMG3054 are coloured in pink. hARG, homoarginine; CHA, cyclohexylalanine; OIC, Octahydroindole-2-carboxylic Acid; NLE, Norleucine; 4-Cl-PHE, 4-choloro-Phenylalanine The original article has been corrected.
Volume
15