Copper-catalyzed one-pot synthesis of α-ketoamides from 1-arylethanols

Date Issued
01-01-2015
Author(s)
Sharma, Nidhi
Kotha, Surya Srinivas
Lahiri, Nabajit
Indian Institute of Technology, Madras
DOI
Abstract
A copper-catalyzed one-pot strategy for the synthesis of α-ketoamides from 1-arylethanols is described. This triple oxidation of 1-arylethanols involves alcohol oxidation, sp3 C-H oxidation, and oxidative amidation with amines. The protocol is highly efficient, delivering α-ketoamides in good to excellent yields.
Volume
47
Subjects