Biocatalytic deracemization of alkyl-2-hydroxy-4-arylbut-3-ynoates using whole cells of Candida parapsilosis ATCC 7330

Saravanan, Thangavel; Anju Chadha

doi:10.1016/j.tetasy.2010.11.021

Biocatalytic deracemization of alkyl-2-hydroxy-4-arylbut-3-ynoates using whole cells of Candida parapsilosis ATCC 7330

Date Issued

20-12-2010

Author(s)

Saravanan, Thangavel

Anju Chadha

Indian Institute of Technology, Madras

DOI

10.1016/j.tetasy.2010.11.021

Abstract

Racemic alkyl-2-hydroxy-4-arylbut-3-ynoates were deracemized to the (S)-alkyl-2-hydroxy-4-arylbut-3-ynoates in excellent enantiomeric excesses (up to >99%) and good isolated yields (up to 81%) with the biocatalyst Candida parapsilosis ATCC 7330. The absolute configuration of the resulting enantiomer was assigned by 1H NMR using Mosher's method. © 2010 Elsevier Ltd. All rights reserved.

Volume

21

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Biocatalytic deracemization of alkyl-2-hydroxy-4-arylbut-3-ynoates using whole cells of Candida parapsilosis ATCC 7330