Publication: Efficient and rapid regioselective deprotection of isopropylidene ketals
Date
01-01-2005
Authors
Indrapal Singh Aidhen
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Abstract
A simple and efficient protocol is described for the regioselective hydrolysis of terminal isopropylidene ketal protection in carbohydrate derivatives 1a-11a. It uses either CoCl2·2H2O in acetonitrile or InCl3 in methanol at temperatures ranging from 50 to 60°C. The low cost of CoCl2·2H2O along with its requirement in catalytic quantities offers a great advantage for the multi-gram scale reaction. © 2005 Verlag der Zeitschrift für Naturforschung.
Description
Keywords
Carbohydrates, Deprotection, Hydrolysis, Isopropylidene Ketals, Regioselectivity