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  1. Home
  2. Indian Institute of Technology Madras
  3. Publication8
  4. Antioxidant properties of Mannich bases
 
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Antioxidant properties of Mannich bases

Date Issued
15-10-2012
Author(s)
Park, Dong Ho
Venkatesan, Jayachandran
Kim, Se Kwon
Ramkumar, Venkatachalm
Parthiban, Paramasivam
DOI
10.1016/j.bmcl.2012.08.080
Abstract
The biological importance of antioxidants influenced to synthesize some curcumin-related compounds as potential antioxidants. Accordingly, a series of 2,4-diaryl-3-azabicyco[3.3.1]nonan-9-ones were synthesized with polyphenolic and/or polymethoxyphenyl groups by modified Mannich condensations. The yield was significantly improved using BF3·SiO2 as heterogeneous catalyst under mild conditions. Stereochemistry of all the synthesized compounds was established as twin-chair with an equatorial disposition of the aryl groups, through their NMR and XRD interpretations. The ABNs 8 (curcumin analog) and 10 (bis-demethoxycurcumin analog) showed an effective profile over curcumin, α-tocopherol, and vitamin C by chemical methods. Further, the efficiency of one of the active molecules, ABN 10, was demonstrated by its intracellular ROS inhibition activity on RAW 264.7 macrophage cells by FACS analysis in dose-dependent manner. © 2012 Elsevier Ltd. All rights reserved.
Volume
22
Subjects
  • BF ·SiO 3 2

  • Crystal structure

  • DPPH assay

  • FACS assay

  • Mannich base

  • Reducing power assay

  • Total antioxidant ass...

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