Study of thermal damage of tissue embedded with blood vessels during photo-thermal heating

The cooling effect of large blood vessels on tissue temperature distribution during photo-thermal heating is predicted using finite element based simulation. A modified Beer-Lambert law is used to model the laser heating. Experiments have been performed on equivalent tissue mimic embedded with simulated blood vessel to validate the simulated results. The result shown that the large blood vessel can take away a significant amount of heat during photo-thermal heating and the corresponding value of damage parameter obtained is insufficient for tissue irreversible damage.