Vicinal Trifluoromethylthioamination of Alkenes with Trifluoromethanesulfenamides

A general and efficient vicinal trifluoromethylthioamination of alkenes has been accomplished at room temperature in the presence of BF3 ⋅ OEt2 using trifluoromethanesulfenamides. Diversely substituted trifluoromethylthiolated amine derivatives were achieved in good yields in a single step. Importantly, trifluoromethanesulfenamides play dual role as ‘SCF3’ and amine source, which allows high atom-efficient approach to access 1-trifluoromethylthio-2-aminoalkane derivatives.