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Efficient Synthesis of Highly Functionalized Spirocarbocyclic Oxindoles through Hauser Annulation
Date Issued
10-10-2017
Author(s)
Lokesh, Kanduru
Indian Institute of Technology, Madras
Abstract
The synthesis of highly functionalized spirocarbocyclic oxindoles was accomplished for the first time, using a Hauser annulation strategy. A reaction between methyleneindolinones and arylsulfonylphthalides catalyzed by cesium carbonate gave access to a new class of biologically important spiro[indoline-3,2′-naphthalene] derivatives in very good yields.
Volume
2017