Porous medium modeling of gestaional age dependent fetal drug exposure

A numerical model for evaluating fetal exposure of maternally administered drugs has been developed. A single repeating functional unit cell of placenta has been modelled as a porous medium species exchanger between mother and fetus. The model is capable of predicting fetal drug concentration with respect to maternal one at any point of perfusion time for any gestational age ranging from 20th week to term pregnancy. It also predicts the possible drug absorption in to chorionic and basal plate tissue.