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Chiral Zn-catalyzed aerobic oxidative kinetic resolution of α-hydroxy ketones
Date Issued
08-03-2011
Author(s)
Muthupandi, Pandi
Indian Institute of Technology, Madras
Abstract
The aerobic oxidative kinetic resolution of racemic α-hydroxy ketones was accomplished using a chiral Zn-quinine complex as the catalyst in the presence of molecular oxygen. The resulting optimized reaction conditions were applied to resolute different types of racemic α-hydroxy ketones and a maximum of 9.2 selectivity (s) was obtained with 88% ee for the recovered α-hydroxy ketone. © 2011 Elsevier Ltd. All rights reserved.
Volume
22