Publication:
A model of the neural substrates for exploratory dynamics in basal ganglia

Simple item page
cris.author.scopus-author-id8408254600
cris.virtual.author-orcid0000-0002-2453-1637
cris.virtual.departmentIndian Institute of Technology, Madras
cris.virtualsource.author-orcid85760e52-4326-470c-93df-57ad9a9b4032
cris.virtualsource.department85760e52-4326-470c-93df-57ad9a9b4032
dc.contributor.authorV Srinivasa Chakravarthy
dc.date.accessioned2023-09-20T05:15:37Z
dc.date.available2023-09-20T05:15:37Z
dc.date.issued01-01-2013
dc.description.abstractWe present a model of basal ganglia (BG) that departs from the classical Go/NoGo picture of the function of its key pathways-the Direct and Indirect Pathways (DP and IP). Between the Go and NoGo regimes, we posit a third Explore regime, which denotes random exploration of action alternatives. Striatal dopamine (DA) is assumed to switch between DP and IP activation. The IP is modeled as a loop of the subthalamic nucleus (STN) and the Globus Pallidus externa (GPe). Simulations reveal that while the model displays Go and NoGo regimes for extreme values of DA, at intermediate values of DA, it exhibits exploratory behavior, which originates from the chaotic activity of the STN-GPe loop. We describe a series of BG models based on Go/Explore/NoGo approach, to explain the role of BG in three cases: (1) a simple action selection task, (2) reaching, and (3) willed action. © 2013 Elsevier B.V.
dc.identifier.doi10.1016/B978-0-444-62604-2.00020-4
dc.identifier.issn796123
dc.identifier.scopus2-s2.0-84872380241
dc.identifier.urihttps://apicris.irins.org/handle/IITM2023/39411
dc.relation.ispartofseriesProgress in Brain Research
dc.sourceProgress in Brain Research
dc.subjectAction selection
dc.subjectBasal ganglia
dc.subjectChaos
dc.subjectDopamine
dc.subjectExploration
dc.subjectReaching
dc.subjectStochastic resonance
dc.subjectWilled action
dc.titleA model of the neural substrates for exploratory dynamics in basal ganglia
dc.typeBook Series
dspace.entity.typePublication
oaire.citation.endPage414
oaire.citation.startPage389
oaire.citation.volume202
oairecerif.author.affiliationIndian Institute of Technology, Madras
person.affiliation.cityChennai
person.affiliation.id60025757
person.affiliation.nameIndian Institute of Technology Madras
Files
Collections
Publication8