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Simple and highly convenient two-step practical procedure for the synthesis of optically pure methyl D-erythro-2,3-dihydroxybutanoate

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Date
01-04-2005
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Abstract
A synthesis of enantiopure methyl D-erythro-2,3-dihydroxybutanoate has been realized using two simple and consecutive reactions on D-erythronolactone as the starting material. The two reactions are lactone ring opening with hydrobromic acid in methanol and subsequent reductive debromination. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
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C -chiral building block 4, Dihydroxy esters, Lactone, Reductive dehalogenation
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