Comment on ‘Thermodynamic database supports deciphering protein–nucleic acid interactions’

Mei and colleagues reported a thermodynamic database, PNATDB for protein-nucleic acid interactions, which contains 12 635 experimentally determined thermodynamic parameters. They claimed that extracting data from existing databases is difficult. ProNAB, which has more than 20 000 experimental data points for binding affinities of protein–nucleic acid complexes and other information, was not discussed.