Publication:
An efficient construction of: N, N -bicyclic pyrazolidinones comprising enaminonitriles via asymmetric [3+2] cycloaddition

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01-01-2016
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Research Projects
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The first thiourea catalysed asymmetric [3+2] cycloaddition reaction between azomethine imines and malanonitriles was developed. Using this novel synthetic strategy, hybrid molecules containing N,N-bicyclic pyrazolidinones fused with enaminonitriles were synthesized in good yields with excellent enantioselectivities (up to 98% ee).
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