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A microfluidic device to select for cells based on chemotactic phenotype
Date Issued
2014
Author(s)
Bajpai, S
Mitchell, MJ
King, MR
Reinhart-King, CA
Abstract
In the search for biomarkers of metastasis, attention has been largely placed on ensemble- averaged measurements that screen for molecules or genes. However, individual molecular changes do not always result in disease, and population- based measurements can mask the molecular signatures of the cells responsible for disease. Here, we describe a device that selects for cells based on chemotactic behavior rather than based on molecular differences, enabling the most aggressive cells to be studied independently from the heterogeneous population.
Volume
2