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Synthesis of benzoxazoles by an efficient ullmann-type intramolecular CO bond-forming coupling cyclization with a BINAM-copper(II) catalyst
Date Issued
15-02-2010
Author(s)
Naidu, Ajay B.
Indian Institute of Technology, Madras
Abstract
A wide range of 2-substituted benzoxazoles were synthesized from the corresponding N-(2-iodophenyl)benzamides through intramolecular CO bond formation via Ullmann-type coupling cyclization in the presence of a catalytic amount of an easily available BINAM-copper(II) complex under very mild reaction conditions (82C). Less reactive bromo and chloro analogues of the N-(2-halophenyl)benzamides were also successfully cyclized to produce benzoxazoles, without increasing the catalyst loading. © Georg Thieme Verlag Stuttgart · New York.