Remote C–H Selenylation of 8-Amidoquinolines via Copper-Catalyzed Radical Cross-Coupling

A copper-catalyzed regioselective C–H selenylation of quinolines with readily available diaryl diselenides is developed based on a chelation-controlled radical cross-coupling strategy. The reaction is scalable, tolerates a wide spectrum of functional groups, and proceeds with excellent C5 regioselectivity to deliver selenoquinolines in high yields (up to 98 %). A single electron transfer (SET) mediated mechanism is proposed.