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Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors
Date Issued
01-01-2004
Author(s)
Singh, Sunil K.
Reddy, P. Ganapati
Rao, K. Srinivasa
Lohray, Braj B.
Misra, P.
Rajjak, Shaikh A.
Rao, Yeleswarapu K.
Venkateswarlu, A.
Abstract
Several chemical modifications in the N1-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro. © 2003 Elsevier Ltd. All rights reserved.
Volume
14