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    Asymmetric-Fluidic-Reservoirs Induced High Rectification Nanofluidic Diode
    (01-12-2018) ;
    Jo, Kyoo
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    Timperman, Aaron
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    Aluru, Narayana R.
    We demonstrate a novel nanofluidic diode that produces rectification factors in excess of 1000. The nanofluidic diode consists of ion permselective nanopores that connect two reservoirs of different diameters- a micropore reservoir and a macropore reservoir. On the application of +100 V to the micropore, a low OFF state current is observed. The OFF state is caused by formation of the ion depleted zone in the micropore because the anions are prevented from entering the nanopores from the micropore and the cations are depleted in this region to maintain charge neutrality. On the application of −100 V, we observe a high ON state current. The ON state is caused by formation of the ion enriched zone in the microchannel because the anions cannot pass through the nanopores and accumulate in the microchannel. To maintain charge neutrality the cations also become enriched in the microchannel. The ratio of ON state current to the OFF state current gives the rectification of current. Here, plasma oxidation is used to achieve a nanopore with a large wall surface charge density of σn = −55 mC/m2 which yields a rectification of current on the order of 3500 that is nearly two orders of magnitude higher than those reported thus far. In contrast to the other nanofluidic diodes, this nanofluidic diode does not introduce asymmetry to the nanopore, but asymmetry is produced by having the nanopores join a micropore and a macropore. Introduction of asymmetry into the fluidic reservoirs which the nanopores connect is quite simple. Hence, the nanofluidic diode is easy to scale up to industrial level.
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    On the Constraint Factor and Tabor Coefficient Pertinent to Spherical Indentation
    (01-12-2018)
    Bodapati, Bolla Reddy
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    Sudharshan Phani, P.
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    Bhattacharjee, P. P.
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    Measuring the uniaxial stress–strain response from indentation testing has been of great interest to the materials community ever since the seminal work on spherical indentation by David Tabor. In this regard, spherical indentation is the primary choice due to the ability to access a wide range of strains in a single test. While indentation testing is fairly simple to perform, the conversion factors required to calculate the uniaxial flow stress from hardness, which is commonly referred to as constraint factor and uniaxial strain from indentation contact radius and ball radius, which is called the Tabor coefficient, are not necessarily constant and most of the prior work involves assumptions about one of these conversion factors to calculate the other. In this work, we present a finite element analysis-based approach to independently determine the constraint factor and Tabor coefficient in the fully plastic indentation regime which is a pre-requisite for this analysis. The criteria to determine whether fully plastic indentation regime is satisfied has also been presented. The proposed approach has been validated by comparing the uniaxial stress–strain response from spherical indentation tests on OFHC copper and the data obtained by conventional uniaxial testing. Excellent agreement has been found between the two approaches which can be readily applied for measuring the uniaxial stress–strain response of coatings which is otherwise difficult to determine.
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    Oxidative stress decreases the redox ratio and folate content in the gut microbe, Enterococcus durans (MTCC 3031)
    (01-12-2018)
    Jose, Steffi
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    Bhalla, Prerna
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    Gut microbiome plays an important role in determining the effectiveness of cancer therapy. The composition of the microbiome is crucial to maintain good digestive health in the host, and to prevent and treat colorectal cancers. Most cancer therapies employ oxidative stress, which disturbs the redox status of the cell, and consequently affect growth, reductive biosynthesis and cell death. Therefore, oxidative stress can undesirably affect the gut microbiome. Hence, it is important to understand the impact of oxidative stress on gut bacteria to devise effective treatment strategies. The current study induces oxidative stress in the model gut bacterium Enterococcus durans (MTCC 3031) with menadione and H2O2. Oxidative stress considerably decreased the redox ratio (NADPH/NADP), an indicator of the redox status, by 55% (menadione) and 28% (H2O2). In addition, an oxidative stress induced decrease in redox ratio decreased folate synthesis by the bacteria, which is an undesirable consequence for the host, since folate deficiency can induce colorectal cancer. Further, oxidative stress considerably decreased growth and the biomass density by 61% (menadione) and 21% (H2O2). Thus, maintenance of the cellular redox status and management of oxidative stress in the gut microbiome may be crucial to the effectiveness of cancer treatment strategies.
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    Nanostructure coated AZ31 magnesium cylindrical mesh cage for potential long bone segmental defect repair applications
    (01-12-2018)
    Perumal, Govindaraj
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    Ramasamy, Boopalan
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    A, Maya Nandkumar
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    This current study is aimed towards the fabrication of AZ31 magnesium cylindrical mesh cage implant with circular holes for orthopedic applications. This mesh cage is coated with nanocomposite material containing polycaprolactone (PCL), pluronic F127 and nano hydroxyapatite (nHA) by electrospinning process. Morphology and composition were analyzed by various characterization techniques. Controlled degradation and weight loss of the nanocomposite coated samples in 28 days were observed when compared with uncoated samples in SBF (simulated body fluid). The nanocomposite coated material was not cytotoxic to MG63 osteosarcoma cells. The cell viability, morphology, ALP activity, calcium mineralization and collagen deposition were also better on this when compared to uncoated. Smooth and randomly deposited nanofibers on the mesh cage was observed and the contact angle indicated that the surface is hydrophilic with (initial contact angle of 55 ± 1° and after 10 s 0°) when compared to PCL (99°) coated surface. 2–5 fold higher mRNA expression levels of osteogenic genes namely ALP, BMP2, COL1 and RUNX2 was observed with nanocomposite coated scaffolds than uncoated and PCL coated samples in 14 days. These results indicate the potential use of the nanocomposite coated AZ31 cylindrical mesh cage for segmental bone defect repair and can be used as a degradable implant for orthopedic applications.
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    Modeling the sensitivity of hydrogeological parameters associated with leaching of uranium transport in an unsaturated porous medium
    (01-12-2018)
    Mohanadhas, Berlin
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    The uranium ore residues from the legacies of past uranium mining and milling activities that resulted from the less stringent environmental standards along with the uranium residues from the existing nuclear power plants continue to be a cause of concern as the final uranium residues are not made safe from radiological and general safety point of view. The deposition of uranium in ponds increases the risk of groundwater getting contaminated as these residues essentially leach through the upper unsaturated geological formation. In this context, a numerical model has been developed in order to forecast the 238 U and its progenies concentration in an unsaturated soil. The developed numerical model is implemented in a hypothetical uranium tailing pond consisting of sandy soil and silty soil types. The numerical results show that the 238 U and its progenies are migrating up to the depth of 90 m and 800 m after 10 y in silty and sandy soil, respectively. Essentially, silt may reduce the risk of contamination in the groundwater for longer time span and at the deeper depths. In general, a coupled effect of sorption and hydro-geological parameters (soil type, moisture context and hydraulic conductivity) decides the resultant uranium transport in subsurface environment.